Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases
Xiu-Yun Zhao1
De-En Xu2
Ming-Lei Wu1
Ji-Chuan Liu1
Zi-Ling Shi1
Quan-Hong Ma1
1.Department of Neurology and Clinical Research Center of Neurological Disease,the Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province,China;Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases,Soochow University,Suzhou,Jiangsu Province,China2.Department of Neurology,Jiangnan University Medical Center,Wuxi,Jiangsu Province,China
摘要：The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular activities.Endoplasmic reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and proteostasis.In this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular requirements.We also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative diseases.In summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve disorders.This review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.
机标关键词：neurodfunctionautophagydegenerativediseasesendoplasmicregulationreticulum
论文发表日期：2025-01-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 6-20 )
英文信息