Microglia lactylation in relation to central nervous system diseases
Hui Yang1
Nan Mo2
Le Tong3
Jianhong Dong1
Ziwei Fan4
Mengxian Jia4
Juanqing Yue5
Ying Wang6
1.School of Pharmacy,Hangzhou Normal University,Hangzhou,Zhejiang Province,China2.Department of Clinical Laboratory,The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People's Hospital),Hangzhou,Zhejiang Province,China3.College of Medical,Veterinary and Life Sciences,University of Glasgow,Glasgow,UK4.Department of Orthopedics(Spine Surgery),the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang Province,China5.Department of Pathology,Affiliated Hangzhou First People's Hospital,Westlake University School of Medicine,Hangzhou,Zhejiang Province,China6.Department of Clinical Research Center,Affiliated Hangzhou First People's Hospital,Westlake University School of Medicine,Hangzhou,Zhejiang Province,China
摘要：The development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis.Microglia,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative diseases.Lactate has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of lactate.Lactylation is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various diseases.This review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting lactate.Finally,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.
机标关键词：relationcentralsystemdiseaseslactylationmicroglianervous
论文发表日期：2025-01-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 29-40 )
英文信息