Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives
Yubo Wang1
Tingli Yuan2
Tianjie Lyu1
Ling Zhang3
Meng Wang4
Zhiying He5
Yongjun Wang6
Zixiao Li6
1.Vascular Neurology,Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing,China;China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital,Capital Medical University,Beijing,China2.Shanghai Engineering Research Center of Stem Cells Translational Medicine,Shanghai,China3.Vascular Neurology,Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing,China4.China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital,Capital Medical University,Beijing,China;National Center for Healthcare Quality Management in Neurological Diseases,Beijing Tiantan Hospital,Capital Medical University,Beijing,China5.Shanghai Engineering Research Center of Stem Cells Translational Medicine,Shanghai,China;Institute for Regenerative Medicine,Shanghai East Hospital,School of Life Sciences and Technology,Tongji University,Shanghai,China6.Vascular Neurology,Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing,China;China National Clinical Research Center for Neurological Diseases,Beijing Tiantan Hospital,Capital Medical University,Beijing,China;National Center for Healthcare Quality Management in Neurological Diseases,Beijing Tiantan Hospital,Capital Medical University,Beijing,China;Chinese Institute for Brain Research,Beijing,China;Research Unit of Artificial Intelligence in Cerebrovascular Disease,Chinese Academy of Medical Sciences,Beijing,China;Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases,Beijing,China
摘要：Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger age.China,in particular,bears a high burden of stroke cases.In recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its treatment.This review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and astrocytes.Additionally,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell therapy.Overall,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient outcomes.Stem cell therapy may potentially become an important component of ischemic stroke treatment.
机标关键词：mechanismcurrentfuturestemstrokecellseffectsevidence
论文发表日期：2025-01-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 67-81 )
英文信息