High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation
Hanki Kim1
Bum Jun Kim1
Seungyon Koh2
Hyo Jin Cho3
Xuelian Jin4
Byung Gon Kim5
Jun Young Choi5
1.Department of Brain Science,Ajou University School of Medicine,Suwon,South Korea;Department of Biomedical Sciences,Ajou University Graduate School of Medicine,Suwon,South Korea2.Department of Brain Science,Ajou University School of Medicine,Suwon,South Korea;Department of Biomedical Sciences,Ajou University Graduate School of Medicine,Suwon,South Korea;Department of Neurology,Ajou University School of Medicine,Suwon,South Korea3.Department of Brain Science,Ajou University School of Medicine,Suwon,South Korea4.Department of Brain Science,Ajou University School of Medicine,Suwon,South Korea;Department of Geriatrics,The Affiliated Suqian First People's Hospital of Nanjing Medical University,Suqian,Jiangsu Province,China5.Department of Brain Science,Ajou University School of Medicine,Suwon,South Korea;Department of Neurology,Ajou University School of Medicine,Suwon,South Korea
摘要：High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and neuroscience.High-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer's disease,frontotemporal dementia,Parkinson's disease,multiple sclerosis,epilepsy,and traumatic brain injury.Several drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system disorders.Although it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system disorders.In this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory role.Research targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.
机标关键词：regenerationcentralmobilitysystemgrouphighbeneathhidden
论文发表日期：2025-01-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：9( 107-115 )
英文信息