Non-coding RNAs in acute ischemic stroke:from brain to periphery
Shuo Li1
Zhaohan Xu1
Shiyao Zhang2
Huiling Sun3
Xiaodan Qin3
Lin Zhu1
Teng Jiang1
Junshan Zhou1
Fuling Yan2
Qiwen Deng1
1.Department of Neurology,Nanjing First Hospital,Nanjing Medical University,Nanjing,Jiangsu Province,China2.Department of Neurology,Zhongda Hospital,School of Medicine,Southeast University,Nanjing,Jiangsu Province,China3.General Clinical Research Center,Nanjing First Hospital,Nanjing Medical University,Nanjing,Jiangsu Province,China
摘要：Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and disability.Accurate predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain undetermined.With innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental models.Differentially expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic stroke.Moreover,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and prognosis.In particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic stroke.In this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke-induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and prognosis.Findings from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.
机标关键词：strokebrainrnasfromacuteischemicnon-codingperiphery
论文发表日期：2025-01-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 116-129 )
英文信息