The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson's disease
Fengjuan Jiao1
Lingyan Meng2
Kang Du2
Xuezhi Li1
1.School of Mental Health,Jining Medical University,Jining,Shandong Province,China;Shandong Collaborative Innovation Center for Diagnosis,Treatment and Behavioral Interventions of Mental Disorders,Institute of Mental Health,Jining Medical University,Jining,Shandong Province,China2.School of Mental Health,Jining Medical University,Jining,Shandong Province,China
摘要：Parkinson's disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such as α-synuclein in neurons.As one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these proteins.Accumulating evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance of α-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson's disease.Moreover,multiple genes associated with the pathogenesis of Parkinson's disease are intimately linked to alterations in the autophagy-lysosome pathway.Thus,this pathway appears to be a promising therapeutic target for treatment of Parkinson's disease.In this review,we briefly introduce the machinery of autophagy.Then,we provide a description of the effects of Parkinson's disease-related genes on the autophagy-lysosome pathway.Finally,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy-lysosome pathway and their applications in Parkinson's disease.
机标关键词：strategiesparkinsonchemicalpathwaytargetgeneautophagydisease
论文发表日期：2025-01-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：20( 139-158 )
英文信息