Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior
Man Han1
Deyang Zeng1
Wei Tan2
Xingxing Chen1
Shuyuan Bai1
Qiong Wu1
Yushan Chen1
Zhen Wei1
Yufei Mei1
Yan Zeng1
1.Brain Science and Advanced Technology Institute,Wuhan University of Science and Technology,Wuhan,Hubei Province,China;Geriatric Hospital Affiliated to Wuhan University of Science and Technology,Wuhan,Hubei Province,China;School of Public Health,Wuhan University of Science and Technology,Wuhan,Hubei Province,China2.Geriatric Hospital Affiliated to Wuhan University of Science and Technology,Wuhan,Hubei Province,China
摘要：Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response.Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region-specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and hippocampus.Determining how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress psychopathology.In this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of depression.We focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor-tropomyosin receptor kinase B signaling pathway and the ventral tegmental area-nucleus accumbens dopamine circuit.We determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic system.Therefore,BDNF might be a biological indicator regulating stress-related processes in various brain regions.
机标关键词：behaviorsocialbrain-deriveddepressive-likefactorneurotrophicregion-specificroles
论文发表日期：2025-01-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 159-173 )
英文信息