Comparing role of ATP between acute pain in neuromyelitis optica spectrum disorder and peripheral neuropathic pain
Teruyuki Ishikura1
Tatsusada Okuno2
1.Department of Molecular Neuroscience,Graduate School of Medicine,Osaka University,Osaka,Japan2.Department of Neurology,Osaka University Graduate School of Medicine,Osaka University,Osaka,Japan
摘要：In this article,we present our previous research,which highlighted adenosine triphosphate(ATP)as the cause of neuropathic pain during the acute phase of neuromyelitis optica spectrum disorder(NMOSD).In NMOSD pathology,damage-associated molecular patterns(DAMPs),including ATP,are released from damaged astrocytes,triggering the activation of innate immune cells.ATP is a central mediator of acute pain in NMOSD.We delve into the mechanisms of ATP in peripheral neuropathic pain,drawing comparisons with our findings in NMOSD.Additionally,we address the intricacies of chronic pain associated with NMOSD.
机标关键词：spectrumbetweenroleacutecomparingdisorderneuromyelitisneuropathic
论文发表日期：2025-01-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 184-185 )