Vascular endothelial growth factor:a double-edged sword in the development of white matter lesions
Narek Manukjan1
Daniel Fulton2
Zubair Ahmed2
W.Matthijs Blankesteijn3
Sébastien Foulquier4
1.Department of Pharmacology and Toxicology,Maastricht University,Maastricht,The Netherlands;CARIM-School for Cardiovascular Diseases,Maastricht University,Maastricht,The Netherlands;Neuroscience and Ophthalmology,Institute of Inflammation and Ageing,University of Birmingham,Edgbaston,Birmingham,UK2.Neuroscience and Ophthalmology,Institute of Inflammation and Ageing,University of Birmingham,Edgbaston,Birmingham,UK;Centre for Trauma Sciences Research,University of Birmingham,Edgbaston,Birmingham,UK3.Department of Pharmacology and Toxicology,Maastricht University,Maastricht,The Netherlands;CARIM-School for Cardiovascular Diseases,Maastricht University,Maastricht,The Netherlands4.Department of Pharmacology and Toxicology,Maastricht University,Maastricht,The Netherlands;MHeNs—School for Mental Health and Neuroscience,Maastricht University,Maastricht,The Netherlands;Department of Neurology,Maastricht University Medical Center,Maastricht,The Netherlands
摘要：As the population ages,the burden of age-related diseases becomes greater.Currently,over 55 million people suffer from dementia worldwide,with Alzheimer's disease being the most common form.However,it is becoming clearer that underlying vascular pathology such as cerebral small vessel disease(cSVD)may be a more detrimental cause for dementia(Cuadrado-Godia et al.,2018).It is estimated that 10％-30％of the elderly population and 35％-90％of all dementia patients exhibit signs of cSVD.The term cSVD refers to pathology affecting the small vessels of the brain,which can lead to lacunar cerebral infarcts,enlarged perivascular spaces,and cortical hemorrhages(Cuadrado-Godia et al.,2018).CSVD is often associated with cognitive decline,gait problems,and dementia(Cuadrado-Godia et al.,2018).To minimize disease progression,preventive measures,and early interventions,such as risk factor management,are crucial.However,due to its asymptomatic nature,the disease is often silent and diagnosed coincidentally at later stages.Thus,the window of opportunity for prevention and treatment is often missed.
机标关键词：developmentwhitegrowthdouble-edgedendothelialfactorlesionsmatter
论文发表日期：2025-01-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 191-192 )