Repetitive transcranial magnetic stimulation in Alzheimer's disease:effects on neural and synaptic rehabilitation
Yi Ji1
Chaoyi Yang1
Xuerui Pang1
Yibing Yan1
Yue Wu2
Zhi Geng1
Wenjie Hu1
Panpan Hu3
Xingqi Wu3
Kai Wang4
1.Department of Neurology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui Province,China;Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders,Hefei,Anhui Province,China2.Department of Neurology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui Province,China3.Department of Neurology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui Province,China;Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders,Hefei,Anhui Province,China;Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health,Hefei,Anhui Province,China4.Department of Neurology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui Province,China;Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders,Hefei,Anhui Province,China;Institute of Artificial Intelligence,Hefei Comprehensive National Science Center,Hefei,Anhui Province,China;Department of Psychology and Sleep Medicine,The Second Affiliated Hospital of Anhui Medical University,Hefei,Anhui Province,China
摘要：Alzheimer's disease is a neurodegenerative disease resulting from deficits in synaptic transmission and homeostasis.The Alzheimer's disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients incapacitated.Repetitive transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological conditions.Over the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and connectivity.It has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological insult.However,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of studies.This study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated mechanisms.This review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer's disease.Apoptotic mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also highlighted.Finally,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.
机标关键词：rehabilitationalzheimerdiseaseeffectsmagneticneuralrepetitivestimulation
论文发表日期：2025-02-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：17( 326-342 )
英文信息