Interleukin 1β receptor and synaptic dysfunction in recurrent brain infection with Herpes simplex virus type-1
Roberto Piacentini
Claudio Grassi
Department of Neuroscience,Università Cattolica del Sacro Cuore,Rome,Italy;Fondazione Policlinico Universitario A.Gemelli,IRCCS,Rome,Italy
摘要：Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer's disease.However,the molecular mechanisms underlying this association are not completely understood.Among the molecular mediators of synaptic and cognitive dysfunction occurring after Herpes simplex virus type-1 infection and reactivation in the brain neuroinflammatory cytokines seem to occupy a central role.Here,we specifically reviewed literature reports dealing with the impact of neuroinflammation on synaptic dysfunction observed after recurrent Herpes simplex virus type-1 reactivation in the brain,highlighting the role of interleukins and,in particular,interleukin 1β as a possible target against Herpes simplex virus type-1-induced neuronal dysfunctions.
机标关键词：receptorsimplexvirusbrainwithdysfunctionherpesinfection
论文发表日期：2025-02-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 416-423 )
英文信息