Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer's disease
Mengqi Hao1
Jianjian Chu2
Tinglin Zhang3
Tong Yin2
Yuankai Gu2
Wendanqi Liang1
Wenbo Ji2
Jianhua Zhuang2
Yan Liu4
Jie Gao3
You Yin5
1.Department of Neurology,Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital),Shanghai,China;School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai,China2.Department of Neurology,Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital),Shanghai,China3.Changhai Clinical Research Unit,Shanghai Changhai Hospital,Naval Medical University,Shanghai,China4.Department of Clinical Pharmacy,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China5.Department of Neurology,Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital),Shanghai,China;Department of Neurology,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai,China
摘要：Alzheimer's disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the brain.Lysosomes,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular homeostasis.Some studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer's disease.Restoring the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer's disease.Currently,the efficacy of drugs in treating Alzheimer's disease is limited,with major challenges in drug delivery efficiency and targeting.Recently,nanomaterials have gained widespread use in Alzheimer's disease drug research owing to their favorable physical and chemical properties.This review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer's disease.This review also explores new concepts and potential therapeutic strategies for Alzheimer's disease through the integration of nanomaterials and modulation of lysosomal function.In conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer's disease.The application of nanotechnology to the development of Alzheimer's disease drugs brings new ideas and approaches for future treatment of this disease.
机标关键词：alzheimerrobustproteinapproachclearancediseaselysosomalmediated
论文发表日期：2025-02-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：16( 424-439 )
英文信息