Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid-beta clearance
Beibei Wu1
Yuqing Liu1
Hongli Li1
Lemei Zhu2
Lingfeng Zeng2
Zhen Zhang3
Weijun Peng4
1.Department of Integrated Traditional Chinese & Western Medicine,The Second Xiangya Hospital,Central South University,Changsha,Hunan Province,China2.Academician Workstation,Changsha Medical University,Changsha,Hunan Province,China3.Department of Integrated Traditional Chinese & Western Medicine,The Second Xiangya Hospital,Central South University,Changsha,Hunan Province,China;Yangsheng College of Traditional Chinese Medicine,Guizhou University of Traditional Chinese Medicine,Guiyang,Guizhou Province,China;Qinhuangdao Shanhaiguan Pharmaceutical Co.,Ltd,Qinhuangdao,Hebei Province,China4.Department of Integrated Traditional Chinese & Western Medicine,The Second Xiangya Hospital,Central South University,Changsha,Hunan Province,China;National Clinical Research Center for Mental Disorder,The Second Xiangya Hospital,Central South University,Changsha,Hunan Province,China
摘要：Alzheimer's disease,the primary cause of dementia,is characterized by neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary tangles.Although amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid-beta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease treatment.Metabolic abnormalities are commonly observed in patients with Alzheimer's disease.The liver is the primary peripheral organ involved in amyloid-beta metabolism,playing a crucial role in the pathophysiology of Alzheimer's disease.Notably,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's disease.In this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid-beta clearance and cholesterol metabolism.Furthermore,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.
机标关键词：alzheimerinsighttargetrolefromamyloid-betacholesterolclearance
论文发表日期：2025-03-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：20( 695-714 )
英文信息