Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases
Minghuang Gao1
Xinyue Wang2
Shijie Su1
Weicheng Feng1
Yaona Lai1
Kongli Huang1
Dandan Cao1
Qi Wang1
1.Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong Province,China;Institute of Clinical Pharmacology,Guangzhou University of Chinese Medicine,Guangzhou,Guangdong Province,China2.The Sixth Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong Province,China
摘要：Meningeal lymphatic vessels form a relationship between the nervous system and periphery,which is relevant in both health and disease.Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation.The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system.In this review,we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network,highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels.Furthermore,we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases,discussing how these interactions shape the pathological outcomes.Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage,cerebrospinal fluid-borne immune modulators,and immune cell populations in aging and neurodegenerative disorders,thereby playing a key role in shaping meningeal and brain parenchyma immunity.
机标关键词：crosstalkcentralneurodvesselcellssystemwithaging
论文发表日期：2025-03-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：16( 763-778 )
英文信息