Infiltration by monocytes of the central nervous system and its role in multiple sclerosis:reflections on therapeutic strategies
Guangyong Zhang1
Qing Yao1
Chubing Long1
Pengcheng Yi1
Jiali Song1
Luojia Wu1
Wei Wan1
Xiuqin Rao1
Yue Lin1
Gen Wei1
Jun Ying1
Fuzhou Hua2
1.Department of Anesthesiology,the Second Affiliated Hospital of Nanchang University,Nanchang,Jiangxi Province,China;Key Laboratory of Anesthesiology of Jiangxi Province,Nanchang,Jiangxi Province,China2.Department of Anesthesiology,the Second Affiliated Hospital of Nanchang University,Nanchang,Jiangxi Province,China
摘要：Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation.Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process.Monocytes play a significant role in neuroinflammation,and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis,leading to improved patient outcomes.This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention:the activation of bone marrow hematopoiesis,migration of monocytes in the blood,and penetration of the blood-brain barrier by monocytes.Finally,we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences.As activated microglia resemble monocyte-derived macrophages,it is important to accurately identify the role of monocyte-derived macrophages in disease.Depending on the roles played by monocyte-derived macrophages at different stages of the disease,several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis.Here,we discuss possible strategies to target monocytes in neurological diseases,focusing on three key aspects of monocyte infiltration into the central nervous system,to provide new ideas for the treatment of neurodegenerative diseases.
机标关键词：strategiescentralsystemroleinfiltrationmonocytesmultiplenervous
论文发表日期：2025-03-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 779-793 )
英文信息