Mitochondrial therapeutics and mitochondrial transfer for neurodegenerative diseases and aging
Neville Ng
Michelle Newbery
Nicole Miles
Lezanne Ooi
Molecular Horizons and School of Chemistry and Molecular Bioscience,University of Wollongong,Wollongong,NSW,Australia
摘要：Mitochondrial dysfunction and neurodegeneration:Progressive neurodegenerative diseases affect a significant proportion of the population;in a single year,there are as many as 276 million disabilities and 9 million deaths as a result of neurological diseases.Mitochondrial function,aging,and neurodegenerative processes appear to be intricately linked;central nervous system degeneration is a major feature of loss-of-function mitochondrial diseases,involving mutation of nuclear or mitochondrial DNA.Meanwhile,mitochondrial dysfunction occurs during healthy aging and is further associated with several neurological diseases,including Alzheimer's disease(AD),Huntington's disease,Friedreich's ataxia,multiple sclerosis,motor neuron disease,Parkinson's disease(PD),and vanishing white matter disease(VWMD)(Figure 1A).Aging increases neurodegenerative risk factors and processes,including progressively impaired cognitive and/or motor function due to cellular dysfunction,senescence,and/or neuronal death.Furthermore,impaired mitochondrial respiration,biogenesis,mitophagy,and axonal transport can be causative factors in dysfunctional protein synthesis,folding,aggregation,and trafficking,as well as inflammation,oxidative stress,and genomic instability.
机标关键词：neurodagingdegenerativediseasesmitochondrialtherapeuticstransfer
论文发表日期：2025-03-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 794-796 )