Mitochondria-cGAS-STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration
José M.Izquierdo
Centro de Biología Molecular Severo Ochoa(CBM),Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM),Madrid,Spain
摘要：The word"senescence"comes from the Latin senescens,meaning"to begin to age",and is characterized by a long-lasting but reversible block in proliferation,resulting from stress-induced cell cycle arrest of previously replication-competent cells.Many stress situations lead to senescence,including telomere shortening,genotoxic stress,oncogene-and oxidative-induced stress,and mitochondrial dysfunction(Mico et al.,2021).It is also characterized by a proinflammatory senescence-associated secretory phenotype(SASP)that potentiates chronic low-grade inflammation and inflammaging-associated dysfunction,resulting in loss of tissue function and health(Figure 1;Mico et al.,2021).
机标关键词：senescenceneurodstingtargetaxiscgasassociateddegeneration
论文发表日期：2025-03-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 805-807 )