Netrin-1 signaling pathway mechanisms in neurodegenerative diseases
Kedong Zhu1
Hualong Wang2
Keqiang Ye3
Guiqin Chen1
Zhaohui Zhang1
1.Department of Neurology,Renmin Hospital of Wuhan University,Wuhan,Hubei Province,China2.Department of Neurology,The First Hospita1 of Hebei Medical University;Brain Aging and Cognitive Neuroscience Laboratory of Heibei Province,Shijiazhuang,Hebei Province,China3.Faculty of Life and Health Sciences,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong Province,China
摘要：Netrin-1 and its receptors play crucial roles in inducing axonal growth and neuronal migration during neuronal development.Their profound impacts then extend into adulthood to encompass the maintenance of neuronal survival and synaptic function.Increasing amounts of evidence highlight several key points:(1)Diminished Netrin-1 levels exacerbate pathological progression in animal models of Alzheimer's disease and Parkinson's disease,and potentially,similar alterations occur in humans.(2)Genetic mutations of Netrin-1 receptors increase an individuals'susceptibility to neurodegenerative disorders.(3)Therapeutic approaches targeting Netrin-1 and its receptors offer the benefits of enhancing memory and motor function.(4)Netrin-1 and its receptors show genetic and epigenetic alterations in a variety of cancers.These findings provide compelling evidence that Netrin-1 and its receptors are crucial targets in neurodegenerative diseases.Through a comprehensive review of Netrin-1 signaling pathways,our objective is to uncover potential therapeutic avenues for neurodegenerative disorders.
机标关键词：netrin-1pathwayneuroddegenerativediseasesmechanismssignaling
论文发表日期：2025-04-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 960-972 )
英文信息