Metabolic reprogramming:a new option for the treatment of spinal cord injury
Jiangjie Chen1
Jinyang Chen1
Chao Yu1
Kaishun Xia1
Biao Yang2
Ronghao Wang1
Yi Li1
Kesi Shi1
Yuang Zhang1
Haibin Xu1
Xuesong Zhang3
Jingkai Wang1
Qixin Chen1
Chengzhen Liang1
1.Department of Orthopedics,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou,Zhejiang Province,China;Orthopedics Research Institute of Zhejiang University,Zhejiang University,Hangzhou,Zhejiang Province,China;Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province,Hangzhou,Zhejiang Province,China;Clinical Research Center of Motor System Disease of Zhejiang Province,Hangzhou,Zhejiang Province,China2.Qiandongnan Prefecture People's Hospital,Kaili,Guizhou Province,China3.Department of Orthopedics,Fourth Medical Center,Chinese PLA General Hospital,Beijing,China
摘要：Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they cause.Despite the ongoing development of various therapies for spinal cord injuries,their effectiveness remains unsatisfactory.However,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic reprogramming.In this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic reprogramming.Normal spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic coupling.However,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial dysfunction.These metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of microglia.To rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell fate.The available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord injury.To further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.
机标关键词：metabolicoptioncordinjuryreprogrammingspinaltreatment
论文发表日期：2025-04-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：16( 1042-1057 )
英文信息