Role of peripheral amyloid-β aggregates in Alzheimer's disease:mechanistic,diagnostic,and therapeutic implications
Nazaret Gamez1
Rodrigo Morales2
1.Department of Neurology,The University of Texas Health Science Center at Houston,Houston,TX,USA2.Department of Neurology,The University of Texas Health Science Center at Houston,Houston,TX,USA;Centro Integrativo de Biologia y Quimica Aplicada(CIBQA),Universidad Bernardo O'Higgins,Santiago,Chile
摘要：Compelling evidence demonstrates that the levels of peripheral amyloid-β(Aβ)fluctuate in Alzheimer's disease(AD)patients.Moreover,Aβdeposits have been identified in peripheral tissues.However,the relevance of peripheral Aβ(misfolded or not)in pathological situations,and the temporal appearance of these pathological fluctuations,are not well understood.The presence of misfolded Aβ in peripheral compartments raises concerns on potential inter-individual transmissions considering the well-reported prion-like properties of this disease-associated protein.The latter is supported by multiple reports demonstrating that Aβ misfolding can be transmitted between humans and experimental animals through multiple routes of exposure.In this mini-review,we discuss the potential implications of peripheral,disease-associated Aβ in disease mechanisms,as well as in diagnostic and therapeutic approaches.
机标关键词：diagnosticalzheimerroleaggregatesamyloid-diseaseimplicationsmechanistic
论文发表日期：2025-04-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 1087-1089 )