Combinatorial therapies for spinal cord injury repair
Carla S.Sousa
Andreia Monteiro
António J.Salgado
Nuno A.Silva
Life and Health Sciences Research Institute(ICVS),School of Medicine,University of Minho,Campus de Gualtar-gualtar,Braga,Portugal;ICVS/3B's Associate Lab,PT Government Associated Lab,Campus de Gualtar-gualtar,Braga,Portugal
摘要：Spinal cord injuries have profound detrimental effects on individuals,regardless of whether they are caused by trauma or non-traumatic events.The compromised regeneration of the spinal cord is primarily attributed to damaged neurons,inhibitory molecules,dysfunctional immune response,and glial scarring.Unfortunately,currently,there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes.Nevertheless,numerous pre-clinical approaches have been studied for spinal cord injury recovery,including using biomaterials,cells,drugs,or technological-based strategies.Combinatorial treatments,which target various aspects of spinal cord injury pathophysiology,have been extensively tested in the last decade.These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration.Thus,this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.
机标关键词：cordcombinatorialinjuryrepairspinaltherapies
论文发表日期：2025-05-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：16( 1293-1308 )
英文信息