Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications
Hassan Saad1
Bachar El Baba1
Ali Tfaily2
Firas Kobeissy3
Juanmarco Gutierrez Gonzalez1
Daniel Refai1
Gerald R.Rodts1
Christian Mustroph1
David Gimbel1
Jonathan Grossberg1
Daniel L.Barrow1
Matthew F.Gary1
Ali M.Alawieh1
1.Department of Neurosurgery,Emory University School of Medicine,Atlanta,GA,USA2.Department of Neurology,Yale University,New Haven,CT,USA3.Center for Neurotrauma,Multiomics & Biomarkers(CNMB),Morehouse School of Medicine,Atlanta,GA,USA
摘要：Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this population.Following the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing research.In this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the pathology.We study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular patterns.Several effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord injury.Following this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human subjects.This review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.
机标关键词：cordfromcomplementdependenteuroimplicationsinflammationinjury
论文发表日期：2025-05-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 1324-1335 )
英文信息