Heterogeneity of mature oligodendrocytes in the central nervous system
Chao Weng1
Adam M.R.Groh2
Moein Yaqubi2
Qiao-Ling Cui2
Jo Anne Stratton2
G.R.Wayne Moore2
Jack P.Antel2
1.Neuroimmunology Unit,Montreal Neurological Institute-Hospital,Department of Neurology and Neurosurgery,McGill University,Montreal,QC,Canada;Department of Neurology,Renmin Hospital of Wuhan University,Wuhan,Hubei Province,China2.Neuroimmunology Unit,Montreal Neurological Institute-Hospital,Department of Neurology and Neurosurgery,McGill University,Montreal,QC,Canada
摘要：Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous system.Recent evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to axons.Despite the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is lacking.We delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature oligodendrocytes.Indeed,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination preferences.Furthermore,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system region.Age and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric disorders.Nevertheless,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined investigations.Future studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte heterogeneity.Such research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,hold promise for the development of therapeutic interventions targeting varied central nervous system pathology.
机标关键词：centralsystemheterogeneitymaturenervousoligodendrocyte
论文发表日期：2025-05-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 1336-1349 )
英文信息