Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration
Ronglin Han1
Lanxin Luo1
Caiyan Wei2
Yaru Qiao1
Jiming Xie1
Xianchao Pan2
Juan Xing1
1.Department of Pathophysiology,School of Basic Medical Sciences,Southwest Medical University,Luzhou,Sichuan Province,China2.Department of Medicinal Chemistry,School of Pharmacy,Southwest Medical University,Luzhou,Sichuan Province,China
摘要：Neuronal growth,extension,branching,and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells.In addition to providing physical support for cells,the extracellular matrix also conveys critical mechanical stiffness cues.During the development of the nervous system,extracellular matrix stiffness plays a central role in guiding neuronal growth,particularly in the context of axonal extension,which is crucial for the formation of neural networks.In neural tissue engineering,manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue.Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system.In this review,we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration.We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments,with an emphasis on their application in neural repair and regeneration,along with a discussion of the current limitations and future prospects.The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.
机标关键词：regenerationenvironmentmatrixgrowthgoodaxonbiomaterialsextracellular
论文发表日期：2025-05-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：13( 1364-1376 )
英文信息