Glia-to-neuron reprogramming to the rescue?
Jack W.Hickmott1
Cindi M.Morshead2
1.Department of Surgery,University of Toronto,Toronto,ON,Canada;Donnelly Centre for Cellular and Biomolecular Research,Toronto,ON,Canada2.Department of Surgery,University of Toronto,Toronto,ON,Canada;Donnelly Centre for Cellular and Biomolecular Research,Toronto,ON,Canada;Institute of Biomedical Engineering,University of Toronto,Toronto,ON,Canada;The KITE Research Institute,Toronto Rehabilitation Institute,University Health Network,Toronto,ON,Canada
摘要：Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The breakthrough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be changed.An exciting extension of the discovery of cell fate impermanence is the direct cellular reprogramming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.A significant body of evidence demonstrates direct cellular reprogramming in vitro(Vasan et al.,2021;Bocchi et al.,2022)and an exciting application of this technology is the use of direct cellular reprogramming in vivo.Indeed,the promise of direct cellular reprogramming to replace lost cells in the central nervous system following neurotrauma or neurodegenerative disease is remarkable.Here we will discuss the hope,the hype,and the scrutiny that surrounds the promise of direct cellular reprogramming,specifically related to the generation of induced neurons from glial cells in vivo.We will highlight successes in the field,examine criticisms of this body of literature,and draw on previous examples of scientific controversy to propose a path forward to"rescue"the field.
机标关键词：glia-to-neuronreprogrammingrescue
论文发表日期：2025-05-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1395-1396 )