Lactate is a potentially harmful substitute for brain glucose fuel:consequences for metabolic restoration of neurotransmission
Oliver Kann1
Lennart Söder2
Babak Khodaie2
1.Institute of Physiology and Pathophysiology,Heidelberg University,Heidelberg,Germany;Interdisciplinary Center for Neurosciences(IZN),Heidelberg University,Heidelberg,Germany2.Institute of Physiology and Pathophysiology,Heidelberg University,Heidelberg,Germany
摘要：The metabolite lactate(L-lactate)can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes(Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose(D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).Lactate production occurs when local glycolysis exceeds oxidative phosphorylation in mitochondria,a complex metabolic process that requires the tricarboxylic acid cycle for pyruvate utilization,the respiratory chain and molecular oxygen as an electron acceptor to finally enable adenosine-5'-triphosphate(ATP)generation(Dienel,2019;Kann,2023).Lactate production is generally favored during hypoxia(anaerobic glycolysis).Alternatively,lactate is generated in the presence of oxygen(aerobic glycolysis),for example,in astrocytes or in neuronal structures that miss mitochondria like a fraction of presynaptic terminals in pyramidal cell axons(Magistretti and Allaman,2018;Kann,2023).Aerobic glycolysis in neurons and glial cells usually results in some net lactate efflux from the active brain to the blood circulation(Dienel,2019).By contrast to lactate,glucose is also required for essential processes such as build-up of glycogen and management of oxidative stress(Dienel,2019;Kann,2023).
机标关键词：metabolicglucoselactatebrainotraconsequenceseurofuel
论文发表日期：2025-05-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1403-1404 )