How dopamine tunes parvalbumin interneurons in the hippocampus:new experimental observations in Alzheimer's disease
Livia La Barbera1
Paraskevi Krashia2
Annalisa Nobili1
1.Department of Medicine and Surgery,Università Campus Bio-Medico di Roma,Via Alvaro del Portillo,Rome,Italy;Department of Experimental Neurosciences,IRCCS Santa Lucia Foundation,Via del Fosso di Fiorano,Rome,Italy2.Department of Experimental Neurosciences,IRCCS Santa Lucia Foundation,Via del Fosso di Fiorano,Rome,Italy;Department of Science and Technology for Sustainable Development and One Health,Università Campus Bio-Medico di Roma,Via Álvaro del Portillo,Rome,Italy
摘要：Despite decades of dedicated research,Alzheimer's disease(AD)is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are still unclear.AD is characterized by featured histological alterations including amyloid-beta(Aβ)plaque deposition,accumulation of neurofibrillary tangles of hyperphosphorylated-tau,and neuronal loss,accompanied by progressive cognitive decline and behavioral changes.The sporadic form of AD primarily affects old individuals(onset around 65 years),leading to difficulties in daily activities along the disease progression.According to the last World Alzheimer Report,the number of patients suffering from AD,together with the economic and social burdens related to the disease,are expected to rapidly increase in the following years.
机标关键词：parvalbuminalzheimerdiseasedopamineexperimentalhippocampusinterneuronsobservations
论文发表日期：2025-05-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1405-1406 )