Peripheral mitochondrial DNA as a neuroinflammatory biomarker for major depressive disorder
Jinmei Ye1
Cong Duan1
Jiaxin Han2
Jinrong Chen2
Ning Sun2
Yuan Li3
Tifei Yuan4
Daihui Peng1
1.Division of Mood Disorder,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China2.Department of Psychiatry,First Hospital of Shanxi Medical University,Taiyuan,Shanxi Province,China3.Shanghai Key Laboratory of Psychotic Disorders,Brain Health Institute,National Center for Mental Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China4.Shanghai Key Laboratory of Psychotic Disorders,Brain Health Institute,National Center for Mental Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,China;Co-Innovation Center of Neuroregeneration,Nantong University,Nantong,Jiangsu Province,China
摘要：In the pathogenesis of major depressive disorder,chronic stress-related neuroinflammation hinders favorable prognosis and antidepressant response.Mitochondrial DNA may be an inflammatory trigger,after its release from stress-induced dysfunctional central nervous system mitochondria into peripheral circulation.This evidence supports the potential use of peripheral mitochondrial DNA as a neuroinflammatory biomarker for the diagnosis and treatment of major depressive disorder.Herein,we critically review the neuroinflammation theory in major depressive disorder,providing compelling evidence that mitochondrial DNA release acts as a critical biological substrate,and that it constitutes the neuroinflammatory disease pathway.After its release,mitochondrial DNA can be carried in the exosomes and transported to extracellular spaces in the central nervous system and peripheral circulation.Detectable exosomes render encaged mitochondrial DNA relatively stable.This mitochondrial DNA in peripheral circulation can thus be directly detected in clinical practice.These characteristics illustrate the potential for mitochondrial DNA to serve as an innovative clinical biomarker and molecular treatment target for major depressive disorder.This review also highlights the future potential value of clinical applications combining mitochondrial DNA with a panel of other biomarkers,to improve diagnostic precision in major depressive disorder.
机标关键词：biomarkerdepressivedisordereuroinflammatorymajormitochondrialperipheral
论文发表日期：2025-06-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 1541-1554 )
英文信息