Potential role of tanycyte-derived neurogenesis in Alzheimer's disease
Guibo Qi1
Han Tang1
Jianian Hu1
Siying Kang1
Song Qin2
1.Department of Anatomy,Histology,and Embryology,School of Basic Medical Sciences,Fudan University,Shanghai,China2.Department of Anatomy,Histology,and Embryology,School of Basic Medical Sciences,Fudan University,Shanghai,China;State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Fudan University,Shanghai,China
摘要：Tanycytes,specialized ependymal cells located in the hypothalamus,play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance.The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood.However,our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited.This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis.Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases.Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease.Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments,which may be disrupted in Alzheimer's disease due to the impaired blood-brain barrier function.However,the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear.Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease,exacerbating neurodegeneration.Confirming this hypothesis,however,poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease.Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases.This line of investigation could provide valuable insights into potential therapeutic strategies for Alzheimer's disease and related conditions.
机标关键词：alzheimerrolederiveddiseaseneurogenesispotentialtanycyte
论文发表日期：2025-06-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 1599-1612 )
英文信息