The potential mechanism and clinical application value of remote ischemic conditioning in stroke
Yajun Zhu
Xiaoguo Li
Xingwei Lei
Liuyang Tang
Daochen Wen
Bo Zeng
Xiaofeng Zhang
Zichao Huang
Zongduo Guo
The First Affiliated Hospital of Chongqing Medical University,Chongqing,China
摘要：Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke.Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation,cellular immunity,apoptosis,and autophagy,the exact underlying molecular mechanisms are unclear.This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways.Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity,non-invasiveness,safety,and patient tolerability.Different forms of remote ischemic conditioning exhibit distinct intervention patterns,timing,and application range.Mechanistically,remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway,improving cerebral perfusion,suppressing neuroinflammation,inhibiting cell apoptosis,activating autophagy,and promoting neural regeneration.While remote ischemic conditioning has shown potential in improving stroke outcomes,its full clinical translation has not yet been achieved.
机标关键词：applicationmechanismclinicalstrokeconditioningischemicpotentialremote
论文发表日期：2025-06-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：15( 1613-1627 )
英文信息