New insights on the role of chondroitin sulfate proteoglycans in neural stem cell-mediated repair in spinal cord injury
Seyed Mojtaba Hosseini1
Soheila Karimi-Abdolrezaee2
1.Department of Physiology and Pathophysiology,Spinal Cord Research Centre,Rady Faculty of Health Sciences,University of Manitoba,Winnipeg,MB,Canada;Manitoba Multiple Sclerosis Research Center,Winnipeg,MB,Canada2.Department of Physiology and Pathophysiology,Spinal Cord Research Centre,Rady Faculty of Health Sciences,University of Manitoba,Winnipeg,MB,Canada;Manitoba Multiple Sclerosis Research Center,Winnipeg,MB,Canada;Children Hospital Research Institute of Manitoba,Winnipeg,MB,Canada
摘要：Extensive neurodegeneration is a hallmark of traumatic spinal cord injury(SCI)that underlies permanent sensorimotor and autonomic impairments(Alizadeh et al.,2019).Following the primary impact,the spinal cord undergoes a cascade of secondary injury mechanisms that are driven by disruption of the blood-spinal cord barrier,vascular injury,glial reactivity,neuroinflammation,oxidative stress,lipid peroxidation,and glutamate excitotoxicity that culminate in neuronal and oligodendroglial cell death,demyelination,and axonal damage(Alizadeh et al.,2019).
机标关键词：insightsstemcordrolecell-mediatedchondroitininjuryneural
论文发表日期：2025-06-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1699-1700 )