Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine,a melatonin metabolite,in the hippocampus:a potential prophylactic agent for dementia
Kazuki Watanabe1
Atsuhiko Hattori2
1.Department of Immunobiology,Institute of Development Aging and Cancer,Tohoku University,Sendai,Miyagi,Japan2.Department of Sport and Wellness,College of Sport and Wellness,Rikkyo University,Niiza,Saitama,Japan
摘要：Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian clock.The hormone is primarily synthesized by the vertebrate pineal gland,but is ubiquitous among invertebrates,unicellular organisms,plants,and even cyanobacteria(Hattori and Suzuki,2024).Melatonin is well-conserved evolutionarily and possesses several physiological functions,such as immune response,bone and glucose metabolism,and memory formation besides regulating the circadian rhythm.
机标关键词：melatoninmemoryagentaminelossacetylaging-induceddecreased
论文发表日期：2025-06-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1705-1706 )