Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus
Haoqi Sun1
Shiqian Shen2
Robert J.Thomas3
M.Brandon Westover1
Can Zhang4
1.Department of Neurology,Beth Israel Deaconess Medical Center,Harvard Medical School,Boston,MA,USA2.Center for Translational Pain Research,Department of Anesthesia,Critical Care and Pain Medicine,Massachusetts General Hospital,Harvard Medical School,Boston,MA,USA3.Division of Pulmonary,Critical Care and Sleep Medicine,Department of Medicine,Beth Israel Deaconess Medical Center,Harvard Medical School,Boston,MA,USA4.Genetics and Aging Research Unit,McCance Center for Brain Health,Mass General Institute for Neurodegenerative Disease,Department of Neurology,Massachusetts General Hospital,Harvard Medical School,Boston,MA,USA
摘要：Introduction:Alzheimer's disease(AD)is a common neurodegenerative disorder and the primary cause of dementia.Considerable evidence supports the"amyloid hypothesis,"stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ),which drives tau phosphorylation,neuroinflammation,and neurodegeneration in the brain.
机标关键词：alzheimernucleuswindowdiseaseemergingregulatereticularroles
论文发表日期：2025-06-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1711-1712 )