Inhibition of the cGAS-STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury
Hang Yang1
Yulei Xia1
Yue Ma1
Mingtong Gao2
Shuai Hou1
Shanshan Xu2
Yanqiang Wang3
1.School of Clinical Medicine,Shandong Second Medical University,Weifang,Shandong Province,China2.Department of Emergency,The Affiliated Hospital of Weifang Medical University,Weifang,Shandong Province,China3.Department of Neurology Ⅱ,The Affiliated Hospital of Weifang Medical University,Weifang,Shandong Province,China
摘要：The cGAS-STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically reviewed.Here,we outline the components of the cGAS-STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood-brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion injury.We further analyze the value of cGAS-STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple mechanisms.Inhibition of the cGAS-STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.
机标关键词：inhibitionischemiapathwaycerebralcgas-stingcontributinginjuryreperfusion
论文发表日期：2025-07-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：19( 1900-1918 )
英文信息