Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration
Paz Cartas-Cejudo
Adriana Cortés
Mercedes Lachén-Montes
Elena Anaya-Cubero
Joaquín Fernández-Irigoyen
Enrique Santamaría
Clinical Neuroproteomics Unit,Proteomics Platform,Navarrabiomed,Hospitalario Universitario de Navarra(HUN),Universidad Publica de Navarra(UPNA),IdiSNA,Navarra Institute for Health Research,Pamplona,Spain
摘要：Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous system.These diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual death.Despite the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining currency.
机标关键词：profilesneurodchallengesdata-drivendegenerationdrugolfactoryomics
论文发表日期：2025-07-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 1997-1998 )