Cryptic exon inclusion in TDP-43 proteinopathies:opportunities and challenges
Lorena Decker
Sonja Menge
Axel Freischmidt
Department of Neurology,Ulm University,Ulm,Germany
摘要：TDP-43 proteinopathies and cryptic exons:Transactive response DNA binding protein of 43 kDa(TDP-43)is a ubiquitously expressed RNA/DNA binding protein crucial for coding and non-coding RNA metabolism including transcription,splicing,transport,translation,and turnover.TDP-43 shuttles between the nucleus and cytoplasm,but is predominantly localized in the nucleus.Neurodegenerative diseases(NDs)may be accompanied by nuclear loss and possible cytoplasmic accumulation and aggregation of TDP-43 in vulnerable neurons and beyond.
机标关键词：exonchallengescrypticinclusionopportunitiesproteinopathies
论文发表日期：2025-07-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2003-2004 )