Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications
Mingyi Yu1
Faith Teo En Ning2
Chang Liu1
Yu-Chi Liu3
1.Tissue Engineering and Stem Cell Group,Singapore Eye Research Institute,Singapore2.Yong Loo Lin School of Medicine,National University of Singapore,Singapore3.Tissue Engineering and Stem Cell Group,Singapore Eye Research Institute,Singapore;Department of Cornea and External Eye Disease,Singapore National Eye Center,Singapore;Ophthalmology and Visual Sciences Academic Clinical Program,Duke-NUS Medical School,Singapore
摘要：Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes mellitus.Diabetic corneal neuropathy refers to the progressive damage of corneal nerves.Diabetic retinopathy has traditionally been considered as damage to the retinal microvasculature.However,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural tissues.Diabetic retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular screening.However,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface impairment.Several studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic hyperglycemia.This review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal neuropathy.We also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.
机标关键词：diagnosticbetweenconnectionscornealdiabeticimplicationsinterconnectionneuropathy
论文发表日期：2025-08-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：12( 2169-2180 )
英文信息