Neuroprotective potential for mitigating ischemia-reperfusion-induced damage
Zi Ye1
Runqing Liu1
Hangxing Wang2
Aizhen Zuo1
Cen Jin3
Nan Wang4
Huiqi Sun5
Luqian Feng6
Hua Yang6
1.The Clinical Medical College,Guizhou Medical University,Guiyang,Guizhou Province,China2.Division of Infectious Diseases,Department of Internal Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China3.School of Medical Imaging,Guizhou Medical University,Guiyang,Guizhou Province,China4.Division of Gastroenterology,First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan Province,China5.The Second Clinical Medical College,Lanzhou University,Lanzhou,Gansu Province,China6.Department of Neurosurgery,Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou Province,China
摘要：Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion injury.Current studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion injury.However,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional exploration.In this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and autophagy.The therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box O.This review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins expression.This review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk factors.While Sirtuins show promise as a potential target for the treatment of cerebral ischemia-reperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuins-targeting drug therapies.Overall,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.
机标关键词：ischemiadamageinducedmitigatingneuroprotectivepotentialreperfusion
论文发表日期：2025-08-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：19( 2199-2217 )
英文信息