C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury
Xiangzi Wang1
Xiaofei Niu2
Yingkai Wang1
Yang Liu1
Cheng Yang3
Xuyi Chen3
Zhongquan Qi4
1.School of Medicine,Guangxi University,Nanning,Guangxi Zhuang Autonomous Region,China2.Graduate School of Tianjin University of Traditional Chinese Medicine,Tianjin,China3.Characteristic Medical Center of People's Armed Police Forces,Tianjin,China4.School of Medicine,Guangxi University,Nanning,Guangxi Zhuang Autonomous Region,China;Fujian Maternity and Child Health Hospital,Fuzhou,Fujian Province,China
摘要：Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory damage.The expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after injury.Recent studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for treatment.This review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord injury.Additionally,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted drugs.Nevertheless,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis.This review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.
机标关键词：mechanismreceptormotifligandpathwaytargetcordchemokine
论文发表日期：2025-08-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：14( 2231-2244 )
英文信息