Decoding molecular mechanisms:brain aging and Alzheimer's disease
Mahnoor Hayat1
Rafay Ali Syed2
Hammad Qaiser3
Mohammad Uzair4
Khalid Al-Regaiey5
Roaa Khallaf6
Lubna Abdullah Mohammed Albassam7
Imdad Kaleem8
Xueyi Wang9
Ran Wang9
Mehwish S.Bhatti10
Shahid Bashir11
1.Atta-ur-Rahman School of Applied Biosciences(ASAB),National University of Sciences and Technology(NUST),Islamabad,Pakistan2.Department of Biotechnology,Quaid-i-Azam University,Islamabad,Pakistan3.Department of Biological Sciences,Faculty of Basic & Applied Sciences,International Islamic University Islamabad(IIUI),Islamabad,Pakistan4.Department of Bioengineering,King Fahd University of Petroleum and Minerals,Dhahran,Saudi Arabia5.Department of Physiology,College of Medicine,King Saud University,Riyadh,Saudi Arabia6.Department of Neurology,Neuroscience Center,King Fahad Specialist Hospital,Dammam,Saudi Arabia7.Department of Mental Health,Neuroscience Center,King Fahad Specialist Hospital,Dammam,Saudi Arabia8.Department of Biosciences,Commission on Science and Technology for Sustainable Development in the South(COMSATS University),Islamabad,Pakistan9.Department of Psychiatry,The First Hospital of Hebei Medical University,Shijiazhuang,Hebei Province,China;Mental Health Institute of Hebei Medical University,Shijiazhuang,Hebei Province,China10.Department of Neurobiology and Behavior,University of California,Irvine,CA,USA11.Neuroscience Center,King Fahad Specialist Hospital Dammam,Dammam,Saudi Arabia
摘要：The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's disease.Beyond these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging brain.Understanding these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect cognition.This review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.
机标关键词：alzheimermolecularbrainagingdecodingdiseasemechanisms
论文发表日期：2025-08-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：21( 2279-2299 )
英文信息