Neurocircuit regeneration by extracellular matrix reprogramming
Shengzhang Su1
Ian N.Levasseur2
Kimberly M.Alonge3
1.Department of Medicinal Chemistry,University of Washington,Seattle,WA,USA;Department of Chemistry,University of Washington,Seattle,WA,USA2.Department of Chemistry,University of Washington,Seattle,WA,USA3.Department of Medicinal Chemistry,University of Washington,Seattle,WA,USA;Department of Medicine,University of Washington Medicine Diabetes Institute,Seattle,WA,USA
摘要：The brain's extracellular matrix(ECM),which is comprised of protein and glycosaminoglycan(GAG)scaffolds,constitutes 20％-40％of the human brain and is considered one of the largest influencers on brain cell functioning(Soles et al.,2023).Synthesized by neural and glial cells,the brain's ECM regulates a myriad of homeostatic cellular processes,including neuronal plasticity and firing(Miyata et al.,2012),cation buffering(Morawski et al.,2015),and glia-neuron interactions(Anderson et al.,2016).Considering the diversity of functions,dynamic remodeling of the brain's ECM indicates that this understudied medium is an active participant in both normal physiology and neurological diseases.
机标关键词：regenerationmatrixextracellularneurocircuitreprogramming
论文发表日期：2025-08-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2300-2301 )