Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials
Siyi Xu1
Junqiu Jia2
Rui Mao3
Xiang Cao4
Yun Xu5
1.Department of Neurology,Nanjing Drum Tower Hospital,Clinical College of Jiangsu University,Nanjing,Jiangsu Province,China2.Department of Neurology,Nanjing Drum Tower Hospital,Chinese Academy of Medical Science & Peking Union Medical College,Nanjing,Jiangsu Province,China3.Department of Neurology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu Province,China4.Department of Neurology,Nanjing Drum Tower Hospital,Clinical College of Jiangsu University,Nanjing,Jiangsu Province,China;Department of Neurology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu Province,China;State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases,Nanjing University,Nanjing,Jiangsu Province,China;Jiangsu Key Laboratory for Molecular Medicine,Medical School of Nanjing University,Nanjing,Jiangsu Province,China;Nanjing Neurology Medical Center,Nanjing,Jiangsu Province,China5.Department of Neurology,Nanjing Drum Tower Hospital,Clinical College of Jiangsu University,Nanjing,Jiangsu Province,China;Department of Neurology,Nanjing Drum Tower Hospital,Chinese Academy of Medical Science & Peking Union Medical College,Nanjing,Jiangsu Province,China;Department of Neurology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu Province,China;State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases,Nanjing University,Nanjing,Jiangsu Province,China;Jiangsu Key Laboratory for Molecular Medicine,Medical School of Nanjing University,Nanjing,Jiangsu Province,China;Nanjing Neurology Medical Center,Nanjing,Jiangsu Province,China
摘要：Acute central nervous system injuries,including ischemic stroke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal cord injury,are a major global health challenge.Identifying optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent priorities.Mitochondria are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell death.Mitophagy,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these events.Recent evidence has highlighted the significant role of mitophagy in acute central nervous system injuries.In this review,we provide a comprehensive overview of the process,classification,and related mechanisms of mitophagy.We also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate mitophagy.In the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.
机标关键词：centralsystemacuteinjuriesmechanismsmitophagynervouspotentials
论文发表日期：2025-09-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：17( 2437-2453 )
英文信息