Apolipoprotein E elicits target-directed miRNA degradation to maintain neuronal integrity
Jiazi Tan1
Chin-Tong Ong2
1.Temasek Life Sciences Laboratory,National University of Singapore,Singapore2.Temasek Life Sciences Laboratory,National University of Singapore,Singapore;Department of Biological Sciences,National University of Singapore,Singapore
摘要：Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous system.There are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.
机标关键词：integritydegradationmirnaapolipoproteinelicitsmaintainneuronaltarget-directed
论文发表日期：2025-09-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2577-2578 )