Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome
Laetitia Aubry1
Timothy Barrett2
Sovan Sarkar3
1.I-STEM,CECS,Corbeil-Essonnes,France;Université Paris-Saclay,Université d'Evry,INSERM,I-STEM,UMR861,Corbeil-Essonnes,France2.Institute of Cancer and Genomic Sciences,Institute of Biomedical Research,College of Medical and Dental Sciences,University of Birmingham,Edgbaston,Birmingham,UK;Department of Endocrinology,Birmingham Women's and Children's Hospital,Steelhouse Lane,Birmingham,UK3.Institute of Cancer and Genomic Sciences,Institute of Biomedical Research,College of Medical and Dental Sciences,University of Birmingham,Edgbaston,Birmingham,UK
摘要：Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the"powerhouse"of the cell.Nevertheless,this organelle is also involved in a plethora of different cellular functions such as calcium(Ca2+)homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,and β-oxidation of fatty acids.
机标关键词：wolframmodelsassociatedmembranemitochondrianeuronalpatient-derivedsyndrome
论文发表日期：2025-09-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2587-2588 )