Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology
Mikio Shimizu1
Tatsusada Okuno2
1.Department of Neurology,Osaka University Graduate School of Medicine,Suita,Japan;Department of Neurology,Osaka General Medical Center,Osaka,Japan2.Department of Neurology,Osaka University Graduate School of Medicine,Suita,Japan
摘要：Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal cord.Patients with ALS develop skeletal muscle weakness,resulting in death from respiratory paralysis,which usually occurs 2-4 years after clinical onset(Goutman et al.,2022).
机标关键词：barrieractinamyotrophicdiseasedisruptionentryexacerbateimplicated
论文发表日期：2025-09-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：2( 2589-2590 )