Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems
Alena Salasova
Anders Nykjær
Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBL Partnership for Molecular Medicine,and Centre of Excellence PROMEMO,Department of Biomedicine,Aarhus University,Aarhus,Denmark
摘要：The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young adulthood.Impaired neurodevelopment can result in various neurological and psychiatric conditions,jointly named neurodevelopmental disorders(NDDs).Today's stringent NDD classification includes intellectual disabilities,communication disorders,autism spectrum disorder,attention-deficit hyperactivity disorder,movement disorders,and specific learning disorders.While the NDD incidence is on the rise,the available therapies are limited and provide only symptomatic relief(Cainelli and Bisiacchi,2022).
机标关键词：systemsdependentdiseasedemerginghealthynervouspotentialprogranulin
论文发表日期：2025-09-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：3( 2591-2593 )