PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives
Tianlong Liu1
Xiaolin Li2
Xiaowei Zhou3
Wei Chen3
Aidong Wen4
Minna Liu5
Yi Ding4
1.Department of Pharmacy,Xijing Hospital,Fourth Military Medical University,Xi'an,Shaanxi Province,China;Department of Pharmacy,The 940 Hospital of Joint Logistics Support Forces of Chinese PLA,Lanzhou,Gansu Province,China2.Department of Pharmacy,The 940 Hospital of Joint Logistics Support Forces of Chinese PLA,Lanzhou,Gansu Province,China3.Department of Pharmacy,The 944 Hospital of Joint Logistics Support Forces of Chinese PLA,Jiuquan,Gansu Province,China4.Department of Pharmacy,Xijing Hospital,Fourth Military Medical University,Xi'an,Shaanxi Province,China5.Department of Nephrology,The 940 Hospital of Joint Logistics Support Forces of Chinese PLA,Lanzhou,Gansu Province,China
摘要：It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic stroke.As a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from researchers.This article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling pathway.The key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca2+overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic stroke.Future investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.
机标关键词：molecularstrokeischemicmechanismsneuroprotectionperspectivessignalingtherapeutic
论文发表日期：2025-10-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：18( 2758-2775 )
英文信息