Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion
Lu Guan1
Mengting Qiu2
Na Li3
Zhengxiang Zhou3
Ru Ye3
Liyan Zhong3
Yashuang Xu3
Junhui Ren3
Yi Liang1
Xiaomei Shao1
Jianqiao Fang1
Junfan Fang1
Junying Du1
1.Department of Neurobiology and Acupuncture Research,Third School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou,Zhejiang Province,China;Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases,Third School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou,Zhejiang Province,China2.Fuchun Community Health Service Center of Fuyang District,Hangzhou,Zhejiang Province,China3.Department of Neurobiology and Acupuncture Research,Third School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou,Zhejiang Province,China
摘要：Pain is often comorbid with emotional disorders such as anxiety and depression.Hyperexcitability of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid neurotransmission.This review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain disorders.Improving understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these conditions.However,the mechanisms that regulate gamma-aminobutyric acidergic systems remain elusive.It is also unclear as to whether the mechanisms are presynaptic or postsynaptic.Further exploration of the complexities of this system may reveal new pathways for research and drug development.
机标关键词：cortexemotiongammaacidergicaminobutyricanteriorcingulatecomorbidity
论文发表日期：2025-10-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：17( 2838-2854 )
英文信息