Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration
Prajakta Deshpande1
Anuradha Venkatakrishnan Chimata1
Amit Singh2
1.Department of Biology,University of Dayton,Dayton,OH,USA2.Department of Biology,University of Dayton,Dayton,OH,USA;Premedical Program,University of Dayton,Dayton,OH,USA;Center for Tissue Regeneration and Engineering at Dayton(TREND),University of Dayton,Dayton,OH,USA;Integrative Science and Engineering Center,University of Dayton,Dayton,OH,USA;Center for Genomic Advocacy(TCGA),Indiana State University,Terre Haute,IN,USA
摘要：Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivotal to basic cellular processes.Close to 80％-90％of proteins are acetylated during translation,which is an irreversible process that affects protein structure,function,life,and localization.In this review,we have discussed the various N-acetyltransferases present in humans,their function,and how they might play a role in diseases.Furthermore,we have focused on N-acetyltransferase 9 and its role in microtubule stability.We have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative diseases.We have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration.
机标关键词：erasneurodfocusltraroledegenerationdiseasesexploring
论文发表日期：2025-10-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：10( 2862-2871 )
英文信息