Functions of nuclear factor Y in nervous system development,function and health
Pedro Moreira
Roger Pocock
Development and Stem Cells Program,Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology,Monash University,Melbourne,VIC,Australia
摘要：Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and enhancers.Over the last 30 years,research has revealed that the nuclear factor Y complex controls many aspects of brain development,including differentiation,axon guidance,homeostasis,disease,and most recently regeneration.However,a complete understanding of transcriptional regulatory networks,including how the nuclear factor Y complex binds to specific CCAAT boxes to perform its function remains elusive.In this review,we explore the nuclear factor Y complex's role and mode of action during brain development,as well as how genomic technologies may expand understanding of this key regulator of gene expression.
机标关键词：developmentsystemfactorfunctionshealthnervousnuclear
论文发表日期：2025-10-27
在线出版日期：2025-08-15（本平台首次上网日期，不代表文献的发表时间）
页数：8( 2887-2894 )
英文信息